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The cuproptosis-related gene PDHA1 may serve as a node linking these pathways, regulating lipid metabolism through its interaction with the PI3K-Akt-mTOR signaling pathway [123] (Figure 5)

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That is why its effect in studies extends far beyond the gastrointestinal tract, where it was originally discovered

Nitroglycerine, bosentan, and darusentan mitigate microcirculatory obstruction by dilating hepatic sinusoid

The minimal unique+razor peptide number was set to 1, and the allowed FDR was 0.01 (1%) for peptide and protein identification